Endocrine Abstracts

Background: Metformin is widely used for treatment of gestational diabetes mellitus. Metformin is considered safe in pregnancy but crosses the placenta. The limited available data of follow-up of children exposed to metformin in utero suggests potential for increased adiposity but mechanisms are unknown. As placental DNA methylation has been linked to later obesity and metformin causes global DNA methylation changes in cancer cell lines we hypothesised that this may be a candi...

Introduction: During gestation diminished maternal insulin sensitivity (IS) increases the availability of fuels allowing fetal growth. Very severe obesity (Class III obesity (OB), BMI≥40 kg/m2) is associated with reduced IS but it is 28 how nutrient availability differs and how this impacts on birth weight versus normal pregnancies (CON). Methods: 213 OB (median (interquartile range) 43.2(41.1–46.3) kg/m2) and 87 CON (BM...